If Cleary was 100% healthy he would be a huge difference maker compared to what he is now. If Bertuzzi and Zetterberg were not constantly nursing injuries and Lidstrom, Datsyuk (been nursing knee injury for most of the year) and Howard were 100%, it has to be them. Otherwise, it's a very close call.
I think Detroit might be the only team capable of having their top 2 centers somewhat contain both Crosby and Malkin. If both teams are completely healthy it's a 7 game series. Flip a coin as to who wins.
If Crosby is out, Detroit in 6 (assuming Datsyuk, Lidstrom, and Howard are healthy.)
The West is much more of a grind than the East which would put Pittsburgh at an advantage (see: '09 Finals).
Whoever stays the healthiest would win.
From a GM, "Detroit is the best team we've played this year. It's not even close. Their puck control is incredible...You have to hope your goalie has a great night to give you a chance."