I cant remember my strategies exactly but I know a lot of people complain about injuries in the leagues I play in and I rarely have my top 6 players out for any significant time.
I use overload for line 1, behind the net for line 2, crash the net for lines 3 and 4. Usually 3 and 4 players get hurt but I emphasize energy and blocking shots on those lines. plus lines 1 and 2 I have as more shooting than cycling.
As for my D I have my top pairing pretty aggressive my 2nd pretty mixed and my 3rd being more cautious.
I also do a collapsing style of defensive play style so shots have a hard time getting through and my players are always near the net to clear rebounds, I use that with a contain puck pressure so that I am almost never caught out of position from being too aggressive.
I use a 1-3-1 so I can pressure the breakout as well as have 3 players protect the blue line and have my last player down low in case the team tries to dump and chase.
In 1 league I am the Predators and I finished the season with the #1 Defense allowing a 2.01 GAA. Rinne was obviously a big reason for that, but in another league I was the Leafs and I traded for Brodeur and my D has been incredible since. With Brodeur compiling a 2.12 GAA in his first 23 games as a Leaf.