Also have never been to both. However, I have watched both the OC and OTH so I do consider myself a bit of an expert. I'd have to say the West Coast is better even though OTH is better than the OC. The weather and lifestyle in Cali seems awesome.
Both are too expensive to live in. At least with the West, you don't get hit with hurricanes but there are the earthquakes (california), the suicides (Washington/Oregon)...but in the East, you got some of the slums (Baltimore, Washington DC), hurricanes, and the rednecks. I take neither.
“The most terrifying fact about the universe is not that it is hostile, but that it is indifferent. If we can come to terms with this indifference and accept the challenges of life within the boundaries of death, our existence as a species can have genuine meaning and fulfillment. However vast the darkness, we must supply our own light.” - Stanley Kubrick
West Coast without a doubt. If I could keep my standard of living and move to the West Coast of the US (I know how general that sounds), I'd do it unless I was living in the suburbs of Washington, D.C. (Virginia -> Especially Alexandria area).
So 1 tiny area of East Coast > West Coast > Rest of East Coast. That's my ranking.